Common Rule (45 CFR 46): Primary federal regulation governing human subjects research in the United States, establishing basic provisions for IRB oversight, informed consent, and protection of human subjects

FDA Regulations (21 CFR Part 50): Federal regulations specific to clinical trials and FDA-regulated research, establishing requirements for informed consent in clinical investigations

HIPAA Privacy Rule: Federal law protecting sensitive patient health information from being disclosed without patient consent, crucial if research involves medical or health information

State Privacy Laws (e.g., CCPA): State-specific privacy regulations, such as the California Consumer Privacy Act, that may impose additional requirements for data collection and processing

COPPA: Children's Online Privacy Protection Act - Federal law requiring special protections when collecting information from children under 13

ESIGN Act and UETA: Federal and state laws governing the legal validity and enforceability of electronic signatures and records

IRB Requirements: Institutional Review Board specific guidelines and requirements for research involving human subjects

ADA Compliance: Americans with Disabilities Act requirements ensuring accessibility of online consent forms for participants with disabilities

GDPR Considerations: European Union's General Data Protection Regulation requirements if research might include EU residents

State Research Regulations: Additional state-specific requirements for conducting research with human subjects

Vulnerable Populations Protections: Special regulatory requirements for research involving vulnerable populations such as children, prisoners, or cognitively impaired individuals